Science behind our Adaptogenic Herbs

Adaptogens are a special class of natural substances that support the proper function of the organs and systems in the body and the bodies response to biological, chemical, environmental, and psychological stress.[1] Rhodiola rosea, Aralia mandshurica and Withalia somnifera have been known for their revitalizing properties for centuries, but only recently their mode of action has been scientifically explained by the theory of adaptogens. Without being direct stimulants, like caffeine, guarana, ma huang and other sympathomimetics, the natural compounds in these plants are able to optimize and sustain energy depending on the need of the organs and systems. Unlike the Adaptogenic compounds, direct stimulants result in a quick temporary energizing effect that fades upon repeated use. Adaptogenic compounds, on the other hand, don’t have an adrenergic activity and their effect on the central nervous system is related to the endorphine system in the brain.[2]

Rhodiola rosea is the most widely studied adaptogenic plant with over 180 phytochemical and clinical peer reviewed studies published on the subject. The plant grows in the arctic regions of Europe and Asia. Relaxity^® delivers Rhodiola rosea and its core adaptogenic compound, rosavin. Several recent state-of-the-art double blind placebo controlled clinical trials confirm beyond a reasonable doubt that Rhodiola supports physical and mental endurance and combats fatigue under stress.[2-5]

Aralia mandshurica contains adaptogenic compounds collectively called aralosides. An extract of this plant has been clinically tested and is used to support physical and psychological aspects of post-flight recovery in helicopter pilots in Russia.[6]

Withalia somnifera also known as “ashwaganda” is typically used as a general tonic in traditional Ayurveda, an ancient system of medicine. Clinically validated applications of “ashwaganda” are related to the plant’s ability to support resistance under stress.[7]

1. Brown, R.P., P.L. Gerbarg, and Z. Ramazanov, Rhodiola rosea: A Phytomedicinal Overview. Herbalgram: Journal of the American Botanical Council, 2002. 56: p. 40-52.

2. De Bock, K., et al., Acute Rhodiola Rosea Intake Can Improve Endurance Exercise Performance. International Journal of Sport Nutrition and Exercise Metabolism, 2004. 14(3): p. 292-301.

3. Spasov, A.A., et al., A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine, 2000. 7(2): p. 85-89.

4. Shevtsov, V.A., et al., A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine, 2003. 10(2-3): p. 95-105.

5. Darbinyan, V., et al., Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine, 2000. 7(5): p. 365-371.

6. Gubchenko, P.P. and N.K. Fruentov, A Comparative Study of Effectiveness of Eleutherococcus and Other Plant Adaptogens as Agents for Enhancing the Working Capacity of the Flying Personnel. Proceedings of the USSR Academy of Science, 1982.

7. Mishra, L.C., B.B. Singh, and S. Dagenais, Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern.Med Rev., 2000. 5(4): p. 334-346.